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    Plasma biomarker screening could improve accuracy, health equity in Alzheimer’s disease diagnosis

    Joseph Reddy, Ph.D.,
    Minerva Carrasquillo, Ph.D.
    Mayo Clinic researchers have identified a new set of molecular markers in blood plasma. This discovery could lead to the development of improved diagnostic tests for Alzheimer’s disease. Alzheimer’s disease is the most common form of dementia, affecting 6.2 million people in the U.S. The Mayo Clinic study, published in eBioMedicine, is…
    Article |

    Lack of sleep increases unhealthy belly fat

    Naima Covassin, Ph.D.,
    Virend Somers, M.D., Ph.D.
    New research from Mayo Clinic shows that lack of sufficient sleep combined with free access to food increases calorie consumption and consequently fat accumulation, especially unhealthy fat inside the belly. Findings from a randomized controlled crossover study led by Naima Covassin, Ph.D., a cardiovascular medicine researcher at Mayo Clinic, show that lack…
    Article |

    Senolytic drugs boost key protective protein

    James Kirkland, M.D., Ph.D.,
    Yi Zhu, Ph.D.
    Mayo Clinic researchers say senolytic drugs can boost a key protein in the body that may protect older people against aspects of aging and a range of diseases. Their findings, which are published in eBioMedicine demonstrate this in mice and human studies. Senolytics developed at Mayo Clinic and given once clear…
    Article |

    Using AI to predict antidepressant outcomes in youth

    Paul Croarkin, D.O., M.S.,
    Arjun P. Athreya, Ph.D., M.S.,
    Liewei Wang, M.D., Ph.D.
    Mayo Clinic researchers have taken the first step in using artificial intelligence (AI) to predict early outcomes with antidepressants in children and adolescents with major depressive disorder, in a study published in The Journal of Child Psychology and Psychiatry. This work resulted from a collaborative effort between the departments of…
    Article |

    Researchers review how sex steroids change gut, vaginal microbiome

    Marina Walther-Antonio, Ph.D.
    It is well-established that the human body’s microbiome ― the bacteria in the gut ― dramatically affects health and disease. However, the role of the gut in women’s health outcomes is largely unknown. Mayo Clinic and Wellesley College researchers focused on how the interactions of steroids on gut and vaginal…
    Article |

    Identifying inherited gene mutations in pancreatic cancer can lead to targeted therapies, better survival

    Niloy Jewel Samadder, M.D.
    Identifying hereditary gene mutations in pancreatic cancer can help determine individualized treatments and potentially prolong survival, according to new Mayo Clinic Center for Individualized Medicine research. In the study, which was published in Clinical and Translational Gastroenterology, nearly 1 in 6 people diagnosed with pancreatic cancer were found to have an inherited cancer-related gene…
    Article |

    Hip decompression surgery may delay the need for implants in people with avascular necrosis

    Rafael J. Sierra, M.D.
    A regenerative alternative to total hip replacement delayed the need for artificial implants by at least seven years for 35% of patients who had surgery to treat avascular necrosis. That condition occurs when blood flow to the hip joint known as the femoral head is constricted, causing bone cells to die.
    Article |

    Regenerative technology uncovers new discoveries in liver disease

    Robert C. Huebert, M.D.,
    Nidhi Jalan Sakrikar, Ph.D.
    Mayo Clinic researchers have developed a method for generating bile duct cells from stem cells. This technology enables them to study important aspects of primary sclerosing cholangitis, a rare bile duct disease that often destroys the liver. Using these regenerative technologies, Robert Huebert, M.D., and Nidhi Jalan Sakrikar, Ph.D., also confirmed that primary sclerosing…
    Podcast |

    Using the immune system to treat stomach cancer

    An emergence of new therapies to treat stomach cancer has received FDA approval in recent years, according to Dr. Lionel Kankeu Fonkoua, a Mayo Clinic oncologist. Over the last year, immunotherapy has been incorporated into the treatment for stomach cancer. Immunotherapy unleashes the immune system to go after the cancer,…
    Article |

    From fasting to a pill? Mayo Clinic scientists explore the biology of caloric restriction

    Eduardo Chini, M.D., Ph.D
    New year, same topics: nutrition, healthy eating and slowing the downhill roll of aging. Eat this, not that — never that — and try this one weird thing to look younger, right? Advice spans the spectrum from dubious to scientifically supported, but there is an approach that sidesteps it all:…
    Article |

    Large-scale exome sequencing project spots disease-fueling mutations to save lives, accelerate discoveries

    Konstantinos N. Lazaridis, M.D.
    Mayo Clinic is sequencing the exomes of tens of thousands of people from diverse backgrounds to investigate large-scale patterns of distinctive mutations that fuel disease. Exome sequencing analyzes almost all the 20,000 genes that provide instructions for making proteins, which play many critical roles in the body. This is where…
    Article |

    Long QT syndrome — Pushing the limits of gene therapy

    Michael J. Ackerman, M.D., PH.D.
    Nearly 25 years ago, a 10-year-old boy was admitted to Mayo Clinic Children’s Center after being rescued from the bottom of a public pool. To resuscitate the boy, first responders delivered a lifesaving shock from an automatic external defibrillator to his chest poolside. Michael Ackerman, M.D., Ph.D., a pediatric resident at the time,…